Course director:
Prof. dr Nevena Divac
1. TIMETABLE 2024/2025 IS AVAILABLE IN THE NEWS SECTION
2. STUDENTS AND GROUPS 2024/2025 ARE AVAILABLE HERE
The main objectives of the course are as follows:
- education of medical students that will enable them to apply the principles of clinical pharmacology and rational pharmacotherapy in clinical practice;
- gaining skills and forming attitudes necessary to recognize and avoid irrational prescription of medicines.
After attending this course students will:
- understand the principle of individualization in pharmacotherapy
- gain knowledge of rational pharmacotherapy of diseases and disorders that are most common in everyday medical practice
- Acquire skills and form attitudes necessary for the evaluation of drug application regime and involvement in decision-making regarding pharmacotherapy
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Professors:
Prof. dr Nina Žigon, Prof. dr Zoran Todorović, Prof. dr Ljiljana Gojković Bukarica, Prof. dr Dragan Obradović, Prof. dr Sonja Vučković, Prof. dr Miroslav Radenković, Prof. dr Milica Bajčetić, Prof. dr Radan Stojanović, Prof. dr Gordana Dragović Lukić, Prof. dr Zorica Nešić, Prof. dr Nevena Divac, Assoc. Prof. dr Dragana Protić, Assoc. Prof. dr Janko Samardžić, Assoc. Prof. dr Katarina Savić Vujović, Assist. Prof. dr Branislava Medić, Assist. Prof. dr Marko Stojanović, Assist. Prof. dr Bojana Božić Cvijan, Assist. Prof. dr Dragana Srebro, Assist. Prof. dr Božana Obradović
Teaching Assistants:
Teach. Assist. dr Marija Matić, Teach. Assist. dr Vladislav Pajović, Teach. Assist. dr Maja Stojković, Teach. Assist. dr Miloš Basailović, dr Milica Radosavljević, dr Miloš Gostimirović, dr Sara Milojević.
CURRICULUM
CLINICAL PHARMACOLOGY
Total classes: 48 hours
Lectures: 12 hours
Seminars: 36 hours (X 3 GROUPS)
Course Director: Prof. dr Nevena Divac
1. Week
Lecture 2 hours: Clinical pharmacology: development of new drugs, preclinical drug testing; clinical trial of drugs; test principles, test methods, test types, test techniques; monitoring the use of medicines after registration, legal regulations on medicines
Seminar 2 hours: Prescription. Principles of rational prescribing practice
2. Week
Lecture 2 hours: The concept of rational use of drugs. Monitoring of side effects and drug interactions in medical practice
Seminar 2 hours: Drug management and monitoring of drug consumption in a health institution.
3. Week
Lecture 2 hours: Evaluation of drug use. Information on medications and prescribing of medications.
Seminar 2 hours: Drug divisions, drug forms. Drugs for external use. Drugs for oral and parenteral administration.
4. Week
Lecture 2 hours: HIV and hepatitis therapy.
Seminar 2 hours: Problem solving: Prescribing drugs to special population groups (children, the elderly, women (pregnancy and lactation), patients with heart, liver or kidney diseases, obese patients)).
5. Week
Lecture 2 hours: Applied clinical pharmacokinetics. Therapeutic drug monitoring.
Seminar 2 hours: Discussion of cases: Significance of drug pharmacokinetics in clinical practice.
6. Week
Lecture 2 hours: Biological drugs. The term biologically similar drugs (biosimilars).
Seminar 2 hours: Fundamentals of pharmacoeconomic analysis.
7. Week
Seminar 3 hours: Intrahospital and outpatient use of antibiotics. Suppression of antimicrobial resistance.
8. Week
Seminar 3 hours: Treatment of the most common infections (genito-urinary, respiratory, skin, eye and oto-rhinolaryngologie infections)
9. Week
Seminar 3 hours: Pain therapy. Palliative treatment. Treatment of spastic conditions.
10. Week
Seminar 3 hours: Therapy of congestive heart failure. Diuretics.
11. Week
Seminar 3 hours: Therapy of ischemic heart disease. Diabetes therapy
12. Week
Seminar 3 hours: Hypertension therapy. Therapy of hyperlipidemia
13. Week
Seminar 3 hours: Therapy of asthma and chronic obstructive pulmonary disease
14. Week
Seminar 3 hours: Anxiety and depression therapy
15. Week
Make-ups and signatures
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Elective Subject:
New Trends in Clinical Pharmacology
Course director: Prof. dr Nevena Divac
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Elective Subject: New Trends in Clinical Pharmacology
Course director:
Number of seminars: 30 hours (15 MS Teams meetings)
Seminar Scheduling: 1st hour – slide presentation,
2nd hour - presenting clinical cases followed by interactive discussion
Final exam: Essay paper (up to 5 pages)
Final mark: Passed / Not passed
CURRICULUM
Current pharmacotherapy of thyroid gland disorders
New drug targets in treatment of heart failure
Clinical pharmacology challenges in intensive care units
Interactions of antiepileptics
The importance of investigating influence of drugs, dietary supplements and herbal medicines on QT interval in development of new pharmacotherapy approaches
Opiophobia
New information in treatment of HIV and HCV infection
New antibiotics in treatment of pseudomembranous colitis
New (vitamin K-independent) oral anticoagulant drugs
Misuse and addictive potential of drugs
Ketamine: therapeutic use and misuse
Pharmacotherapy of rare diseases
Treatment challenges in geriatric population
New knowledge of etiopathogenesis of Alzheimer's disease and its role for pharmacotherapeutic approach
The influence of sex differences on the choice of treatment: hypertension treatment in women
Basic Litarature
Katzung B et al. (eds.). Basic & Clinical Pharmacology (15th ed.)
Grading policy (2024/25)
PRE-EXAM OBLIGATIONS (Up to 30 points)
One colloquium - test of 20 questions (up to 20 points), points for the presence at seminars (up to 4 points), and the activity points for active participation in seminars (up to 6 points).
Colloquium
Colloquium consists of 20 questions. Questions are formed in a way in which a student chooses only one correct answer out of 4 offered. The first test and the makeup test (re-test) will be organized. Re-test can be taken only by students who did not pass the first test or can justify in written form the absence from the first test. A re-test will be organized no later than 14 days after the first test.
Colloquium consists of 20 questions and it is scored as follows:
20 correct answers - 20 points
19 correct answers - 19 points
18 correct answers - 18 points
17 correct answers - 17 points
16 correct answers - 16 points
15 correct answers - 15 points
14 correct answers - 14 points
13 correct answers - 13 points
12 correct answers - 12 points
11 correct answers - 11 points
10 correct answers - 10 points
09 correct answers - 9 points
08 corrects answers - 8 points
07 correct answers - 7 points
06 correct answers - 6 points
05 correct points - 5 points
04 correct answers - 4 points
03 correct answers - 3 points
02 correct answers - 2 poinrs
01 correct answers - 1 point
Presence at seminars
For obtaining the signature, minimum 9-weeks presence is requested, 1-week absence is allowed, the rest of absences go through make-ups.
10-weeks presence = 2 points
11-weeks presence = 3 points
12-weeks and more presence = 4 points
Activity points - Seminars (active involvement, discussions, resolving relevant questions...)
1 mark in the chart = 2 points
2 marks in the chart = 4 points
3 and more marks = 6 points
The total number of points achieved by students through the pre-exam activities (maximum 30) is permanent.
FINAL EXAM
Students take the final test, consisting of 30 questions that cover the entire course content from Clinical Pharmacology that they attended during the semester XI.
The mark obtained in the final test yields the following points:
16-18 correct answers - passed six (6) - 42 points
19-21 correct answers - passed seven (7) - 49 points
22-24 correct answers - passed eight (8) - 56 points
25-27 correct answers - passed nine (9) - 63 points
28-30 correct answers - passed ten (10) - 70 points
FINAL SCORE
Regularity in attendance and class participation - up to 10 points
The colloquium - up to 20 points
Final test - up to 70 points
Points gained through the pre-exam activities (up to 30 points) and obtained on the final test (up to 70 points) are added together for a final score.
The final score contains up to 100 points and is determined according to the following scale:
51-60 points - mark 6 (six)
61-70 points - mark 7 (seven)
71-80 points - mark 8 (eight)
81-90 points - mark 9 (nine)
91-100 points - mark 10 (ten)
Research topics
Course director:
Prof. dr Nevena Divac
nevena.divac@med.bg.ac.rs