Professors:

Prof. dr Nina Žigon, Prof. dr Zoran Todorović, Prof. dr Ljiljana Gojković Bukarica, Prof. dr Dragan Obradović, Prof. dr Sonja Vučković, Prof. dr Miroslav Radenković, Prof. dr Milica Bajčetić, Prof. dr Radan Stojanović, Prof. dr Gordana Dragović Lukić, Prof. dr Zorica Nešić, Prof. dr Nevena Divac, Assoc. Prof. dr Dragana Protić, Assoc. Prof. dr Janko Samardžić, Assoc. Prof. dr Katarina Savić Vujović, Assist. Prof. dr Branislava Medić, Assist. Prof. dr Marko Stojanović, Assist. Prof. dr Bojana Božić Cvijan, Assist. Prof. dr Dragana Srebro

Teaching Assistants:

Teach. Assist. dr Božana Obradović, Teach. Assist. dr Marija Matić, Teach. Assist. dr Vladislav Pajović, Teach. Assist. dr Maja Stojković, Teach. Assist. dr Miloš Basailović, dr Milica Radosavljević, dr Miloš Gostimirović, dr Sara Milojević.

CURRICULUM

CLINICAL PHARMACOLOGY

Total classes: 48 hours

Lectures: 12 hours

Seminars: 36 hours (X 3 GROUPS)

Course Director: Prof. dr Miroslav Radenkovic

1. Week

Lecture 2 hours: Clinical pharmacology: development of new drugs, preclinical drug testing; clinical trial of drugs; test principles, test methods, test types, test techniques; monitoring the use of medicines after registration, legal regulations on medicines

Seminar 2 hours: Prescription. Principles of rational prescribing practice

2. Week

Lecture 2 hours: The concept of rational use of drugs. Monitoring of side effects and drug interactions in medical practice

Seminar 2 hours: Drug management and monitoring of drug consumption in a health institution.

3. Week

Lecture 2 hours: Evaluation of drug use. Information on medications and prescribing of medications.

Seminar 2 hours: Drug divisions, drug forms. Drugs for external use. Drugs for oral and parenteral  administration.

4. Week

Lecture 2 hours: HIV and hepatitis therapy.

Seminar 2 hours: Problem solving: Prescribing drugs to special population groups (children, the elderly, women (pregnancy and lactation), patients with heart, liver or kidney diseases, obese patients)).

5. Week

Lecture 2 hours: Applied clinical pharmacokinetics. Therapeutic drug monitoring.

Seminar 2 hours: Discussion of cases: Significance of drug pharmacokinetics in clinical practice.

6. Week

Lecture 2 hours: Biological drugs. The term biologically similar drugs (biosimilars).

Seminar 2 hours: Fundamentals of pharmacoeconomic analysis.

7. Week

Seminar 3 hours: Intrahospital and outpatient use of antibiotics. Suppression of antimicrobial resistance.

8. Week

Seminar 3 hours: Treatment of the most common infections (genito-urinary, respiratory, skin, eye and oto-rhinolaryngologie infections)

9. Week

Seminar 3 hours: Pain therapy. Palliative treatment. Treatment of spastic conditions.

10. Week

Seminar 3 hours: Therapy of congestive heart failure. Diuretics.

11. Week

Seminar 3 hours: Therapy of ischemic heart disease. Diabetes therapy

12. Week

Seminar 3 hours: Hypertension therapy. Therapy of hyperlipidemia

13. Week

Seminar 3 hours: Therapy of asthma and chronic obstructive pulmonary disease

14. Week

Seminar 3 hours: Anxiety and depression therapy

15. Week
Make-ups and signatures

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Elective Subject: 
New Trends in Clinical Pharmacology

Course director:
Prof. dr Miroslav Radenković

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Elective Subject:              New Trends in Clinical Pharmacology

Course director:               Prof. dr Miroslav Radenković

Number of seminars:     30 hours (15 MS Teams meetings)

Seminar Scheduling:      1^st hour – slide presentation,

                                           2^nd hour - presenting clinical cases followed by interactive discussion 

Final exam:                        Essay paper (up to 5 pages)

Final mark:                         Passed / Not passed

CURRICULUM

Current pharmacotherapy of thyroid gland disorders

New drug targets in treatment of heart failure

Clinical pharmacology challenges in intensive care units

Interactions of antiepileptics

The importance of investigating influence of drugs, dietary supplements and herbal medicines on QT interval in development of new pharmacotherapy approaches

Opiophobia

New information in treatment of HIV and HCV infection

New antibiotics in treatment of pseudomembranous colitis

New (vitamin K-independent) oral anticoagulant drugs

Misuse and addictive potential of drugs

Ketamine: therapeutic use and misuse

Pharmacotherapy of rare diseases

Treatment challenges in geriatric population

New knowledge of etiopathogenesis of Alzheimer's disease and its role for pharmacotherapeutic approach

The influence of sex differences on the choice of treatment: hypertension treatment in women

Basic Litarature

Katzung B et al. (eds.). Basic & Clinical Pharmacology (15th ed.)

Grading policy (2023/24)

PRE-EXAM OBLIGATIONS (Up to 30 points)

One colloquium - test of 20 questions (up to 20 points), points for the presence at seminars (up to 4 points), and the activity points for active participation in seminars (up to 6 points).

Colloquium

Colloquium consists of 20 questions. Questions are formed in a way in which a student chooses only one correct answer out of 4 offered. The first test and the makeup test (re-test) will be organized. Re-test can be taken only by students who did not pass the first test or can justify in written form the absence from the first test. A re-test will be organized no later than 14 days after the first test.

Colloquium consists of 20 questions and it is scored as follows:

20 correct answers - 20 points

19 correct answers - 19 points

18 correct answers - 18 points

17 correct answers - 17 points

16 correct answers - 16 points

15 correct answers - 15 points

14 correct answers - 14 points

13 correct answers - 13 points

12 correct answers - 12 points

11 correct answers - 11 points

0-10 correct answers - 0 points

Presence at seminars

For obtaining the signature, minimum 9-weeks presence is requested, 1-week absence is allowed, the rest of absences go through make-ups.  

10-weeks presence                         = 2 points

11-weeks presence                         = 3 points

12-weeks and more presence         = 4 points

Activity points - Seminars (active involvement, discussions, resolving relevant questions...)

1 mark in the chart          = 2 points

2 marks in the chart        = 4 points

3 and more marks           = 6 points

The total number of points achieved by students through the pre-exam activities (maximum 30) will be written in the cards after completion of sets (total score) and taken into account for the final assessment for the two following academic years (therefore, for students who attend the course in 2023-24 the results remain valid until the end of October 2025). After two academic years (after October 2025) all passed tests and gained points will not be valid anymore.

FINAL EXAM (Starting from October 01, 2023)

Students take the final test, consisting of 30 questions that cover the entire course content from Clinical Pharmacology that they attended during the semester XI.

The mark obtained in the final test yields the following points:

16-18 correct answers       - passed six (6) - 42 points

19-21 correct answers - passed seven (7) - 49 points

22-24 correct answers - passed eight (8) - 56 points

25-27 correct answers - passed nine (9) - 63 points

28-30 correct answers - passed ten (10) - 70 points

FINAL SCORE

Regularity in attendance and class participation - up to 10 points

The colloquium - up to 20 points

Final test - up to 70 points

Points gained through the pre-exam activities (up to 30 points) and obtained on the final test (up to 70 points) are added together for a final score.

The final score contains up to 100 points and is determined according to the following scale:

51-60 points - mark 6 (six)

61-70 points - mark 7 (seven)

71-80 points - mark 8 (eight)

81-90 points - mark 9 (nine)

91-100 points - mark 10 (ten)

Course director:

Prof. dr Miroslav Radenković

miroslav.radenkovic@med.bg.ac.rs